Protein Details: Aquaporin-B

Protein ID

ICDB_Pro_0968

Protein Name

Aquaporin-B

Gene Name

aqpB; DDB_G0279443

Organism

Dictyostelium discoideum (Social amoeba)

Length

294 amino acids

AlphaFoldDB

AF-Q54WT8-F1-model_v4.pdb

Function

Putatively gated water-specific channel; requiring a cysteine residue within the channel. Impermeable to water; glycerol and urea when expressed in Xenopus oocytes. Not regulated by pH; channels remain impermeable to water at pH 7.4 and 5.2.

Sequence

MSLKRSDDYQDLEEGIAMEDGGNIKDEEEKPLDPIEEQNKKRWVLIRAVLGELLCTFLFVYVLCATSANFIRLGSPPNPVVGGLSTGFAAVALIYSFADVSGAHFNPAVTFATCVTRKTSITKGLMYVGAQLVGSVLASLILLATFPGNFPGDKNAASAVAIAPSTDANIGNAFLTELVLTFILVYVIFAVAFDTVDNSVKTKVVGKSSSNNLTIYTTSGQTKAGFAPIAIGFTLGFLCFLGGSVSGGAFNPARVFGTALVGNNWTRHWMYWIADFLGAGLAGFAQKFFSSTHK

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

SITE 239: "Selectivity filter"

Disease

Location

DOI ID

10.1074/jbc.m111.329102; 10.1038/nature03481

RefSeq

XP_641629.1